Antibiotic resistance has become a global health problem in both clinical and community settings.

Our lab is interested in the structure-based design of inhibitors that either block existing antibiotic-resistance mechanisms or provide novel antibiotic therapies by targeting macromolecular assemblies essential to bacterial viability and/or pathogenesis.

Find out what we’re working on…

Salmonella typhimurium uses the SPI-1 type III secretion system to invade host cells. Our lab uses an integrated experimental and bioinformatic approach to investigate the structure of this macromolecular assembly. The background image shows a color-enhanced scanning electron micrograph of S. typhimurium (red) invading cultured human cells.
(Credit: Rocky Mountain Laboratories,NIAID,NIH).

Contact Us

Dr. Natalie Strynadka
Dept. of Biochemistry and Molecular Biology
University of British Columbia
Life Sciences Centre
2350 Health Sciences Mall
Vancouver, British Columbia, Canada
V6T 1Z3

Wet Lab: 604.822.7729
Computing Lab: 604.822.8032
Fax: 604.822.5227

Email: ncjs(at)

Map & Directions »

Lab News

  • September 2014

    Welcome new graduate students Sean, Andrew and Franco to the lab.

  • June 2014

    Congratulations to Dustin for his contribution to paper in Nature identifying an inhibitor of NDM-1.

  • March 2014

    Welcome new postdocs Christian Lizak and Natalie Zeytuni.